When you setup payroll for the first time, you need to enroll in EFTPS to pay your federal payroll taxes electronically. Make sure to have your EIN number and a check for the bank account that you will pay the taxes from to complete enrollment. Go to www.eftps.gov and click “ENROLLMENT” and follow the instructions from there. Once you enroll onine, you will get a letter in the mail with a PIN and a phone number to call to complete the enrollment in 5 to 7 business days.